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Clin Nucl Med. 2016 Jun;41(6):510-1. doi: 10.1097/RLU.0000000000001209.

Fibrous Dysplasia Presenting as a Cold Spot in 18F-FLT PET/CT Imaging.

Author information

1
From the *Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University and Masaryk Memorial Cancer Institute, Zluty kopec, Brno, Czech Republic; †Department of Nuclear Medicine, PET Center, RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec, Brno, Czech Republic; ‡1st Department of Pathological Anatomy, Faculty of Medicine, Masaryk University and St. Anne's University Hospital, Pekarska, Brno, Czech Republic; and §Department of Radiation Oncology, Faculty of Medicine, Masaryk University and Masaryk Memorial Cancer Institute, Zluty kopec, Brno, Czech Republic.

Abstract

Fibrous dysplasia (FD) is a benign bone lesion in which normal bone marrow is replaced by fibro-osseous tissue. The usual high fluorodeoxyglucose (F-FDG) uptake in FD may lead to the misdiagnosis of bone malignancy. Herein, we describe the case of a 42-year old man with histologically verified FD of the pubic bone, which has been subsequently examined during follow-up for rectal cancer, using both F-FDG and fluorothymidine (F-FLT) PET/CT imaging. The FD lesion was characterized by a high uptake of F-FDG (hot spot) but very low uptake of F-FLT (cold spot) as compared with the contralateral unaffected pubic bone.

PMID:
27055128
DOI:
10.1097/RLU.0000000000001209
[Indexed for MEDLINE]

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