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ACS Appl Mater Interfaces. 2016 Apr 27;8(16):10183-92. doi: 10.1021/acsami.6b01243. Epub 2016 Apr 14.

Biointerface by Cell Growth on Graphene Oxide Doped Bacterial Cellulose/Poly(3,4-ethylenedioxythiophene) Nanofibers.

Author information

1
Institute of Chemicobiology and Functional Materials, School of Chemical Engineering, Nanjing University of Science and Technology , 200 Xiao Ling Wei Street, Nanjing, Jiangsu Province, China.
2
Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University , 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, Jiangsu Province, China.
3
School of Radiation Medicine and Protection and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University , 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, Jiangsu Province, China.
4
Lianyungang Normal College , Lianyungang, Jiangsu, China.

Abstract

Highly biocompatible advanced materials with excellent electroactivity are increasingly meaningful to biointerfaces and the development of biomedicine. Herein, bacterial cellulose/poly(3,4-ethylene dioxythiophene)/graphene oxide (BC/PEDOT/GO) composite nanofibers were synthesized through the in situ interfacial polymerization of PEDOT with the doping of GO. The abundant free carboxyl and hydroxy groups offer the BC/PEDOT/GO film active functional groups for surface modification. We demonstrate the use of this composite nanofiber for the electrical stimulation of PC12 neural cells as this resultant nanofiber scaffold could closely mimic the structure of the native extracellular matrix (ECM) with a promoting cell orientation and differentiation after electrical stimulation of PC12 cells. It is expected that this biocompatible BC/PEDOT/GO material will find potential applications in biological and regenerative medicine.

KEYWORDS:

bacterial cellulose nanofibers; biointerface; electrical stimulus; graphene oxide; poly(3,4-ethylenedioxythiophene)

PMID:
27054801
DOI:
10.1021/acsami.6b01243
[Indexed for MEDLINE]

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