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World J Gastroenterol. 2016 Apr 7;22(13):3663-9. doi: 10.3748/wjg.v22.i13.3663.

Prevalence of and risk factors for non-alcoholic fatty liver disease in a Chinese population: An 8-year follow-up study.

Author information

1
Zhen-Ya Lu, Department of Internal Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Abstract

AIM:

To investigate the prevalence of and risk factors for non-alcoholic fatty liver disease (NAFLD) in a Chinese population.

METHODS:

A total of 1948 adults from China was followed for 8 years. A cross-sectional study was performed to investigate the prevalence of NAFLD at baseline, and then the participants were followed for 8 years to investigate risk factors for the development of NAFLD.

RESULTS:

A total of 1948 participants were enrolled at baseline, of whom 691 were diagnosed with NAFLD. During the 8-year follow-up, 337 baseline NAFLD-free participants developed NAFLD. They had a greater increase in body mass index (BMI), serum uric acid, fasting plasma glucose, very low-density lipoprotein cholesterol and a considerable decrease in high-density lipoprotein cholesterol. 123 participants who had NAFLD at baseline lost NAFLD during the 8-year follow-up period. They had a greater decrease in BMI, fasting plasma glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, and γ-glutamyl transpeptidase.

CONCLUSION:

NAFLD is prevalent in Chinese population with a rapidly increasing tendency. It can be reversed when patients lose their weight, control their hyperlipidemia and hyperglycemia, and reduce the liver enzyme levels.

KEYWORDS:

Follow-up; Non-alcoholic fatty liver disease; Prevalence; Risk factors

PMID:
27053858
PMCID:
PMC4814652
DOI:
10.3748/wjg.v22.i13.3663
[Indexed for MEDLINE]
Free PMC Article

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