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Nat Rev Neurosci. 2016 May;17(5):282-92. doi: 10.1038/nrn.2016.24. Epub 2016 Apr 7.

Neurotrophic factor control of satiety and body weight.

Author information

1
Department of Neuroscience, The Scripps Research Institute Florida, 130 Scripps Way, Jupiter, Florida 33458, USA.

Abstract

Energy balance--that is, the relationship between energy intake and energy expenditure--is regulated by a complex interplay of hormones, brain circuits and peripheral tissues. Leptin is an adipocyte-derived cytokine that suppresses appetite and increases energy expenditure. Ironically, obese individuals have high levels of plasma leptin and are resistant to leptin treatment. Neurotrophic factors, particularly ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF), are also important for the control of body weight. CNTF can overcome leptin resistance in order to reduce body weight, although CNTF and leptin activate similar signalling cascades. Mutations in the gene encoding BDNF lead to insatiable appetite and severe obesity.

PMID:
27052383
PMCID:
PMC4898883
DOI:
10.1038/nrn.2016.24
[Indexed for MEDLINE]
Free PMC Article

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