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Trends Genet. 2016 Jun;32(6):320-321. doi: 10.1016/j.tig.2016.03.006. Epub 2016 Apr 2.

Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.

Author information

1
Department of Biochemistry and Molecular Biology, Medical Scientist Training Program, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.
2
Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics and Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA. Electronic address: chuanhe@uchicago.edu.

Abstract

N(6)-Methyladenosine (m(6)A) is emerging as a chemical mark that broadly affects the flow of genetic information in various biological processes in eukaryotes. Recently, Xiao et al. reported that the nuclear m(6)A reader protein YTHDC1 impacts mRNA splicing, providing a transcriptome-wide glance of splicing changes affected by this mRNA methylation reader protein.

KEYWORDS:

N(6)-methyladenosine; YTHDC1; mRNA splicing

PMID:
27050931
DOI:
10.1016/j.tig.2016.03.006
[Indexed for MEDLINE]

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