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Reprod Toxicol. 2016 Jun;61:186-94. doi: 10.1016/j.reprotox.2016.03.045. Epub 2016 Apr 2.

Perinatal exposure to mixtures of endocrine disrupting chemicals reduces female rat follicle reserves and accelerates reproductive aging.

Author information

1
Division of Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Søborg DK-2860, Denmark.
2
Division of Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Søborg DK-2860, Denmark. Electronic address: jubo@food.dtu.dk.

Abstract

Exposure to endocrine disrupting chemicals (EDCs) during development can have negative consequences later in life. In this study we investigated the effect of perinatal exposure to mixtures of human relevant EDCs on the female reproductive system. Rat dams were exposed to a mixture of phthalates, pesticides, UV-filters, bisphenol A, butylparaben, as well as paracetamol. The compounds were tested together (Totalmix) or in subgroups with anti-androgenic (AAmix) or estrogenic (Emix) potentials. Paracetamol was tested separately. In pre-pubertal rats, a significant reduction in primordial follicle numbers was seen in AAmix and PM groups, and reduced plasma levels of prolactin was seen in AAmix. In one-year-old animals, the incidence of irregular estrous cycles was higher after Totalmix-exposure and reduced ovary weights were seen in Totalmix, AAmix, and PM groups. These findings resemble premature ovarian insufficiency in humans, and raises concern regarding potential effects of mixtures of EDCs on female reproductive function.

KEYWORDS:

Anti-androgen; Endocrine disruption; Estrous cycle; Female reproductive system; Follicle; Ovarian toxicology; Reproductive senescence

PMID:
27049580
DOI:
10.1016/j.reprotox.2016.03.045
[Indexed for MEDLINE]

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