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J Neuroimmunol. 2016 Apr 15;293:34-8. doi: 10.1016/j.jneuroim.2016.02.002. Epub 2016 Feb 21.

Prevalence of antineuronal antibodies in patients with encephalopathy of unknown etiology: Data from a nationwide registry in Korea.

Author information

1
Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
2
Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea; Departments of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul, South Korea.
3
Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea.
4
Department of Neurology, Asan Medical Center, Seoul, South Korea.
5
Department of Neurology, Samsung Medical Center, Seoul, South Korea.
6
Department of Neurology, Ajou University Medical Center, Suwon, South Korea.
7
Department of Neurology, Catholic University of Korea Yeouido St. Mary's Hospital, Seoul, South Korea.
8
Department of Neurology, Konkuk University, Seoul, South Korea.
9
Department of Neurology, CHA University, CHA Bundang Medical Center, Seongnam, South Korea.
10
Department of Neurology, Korea University Anam Hospital, Seoul, South Korea.
11
Kyungpook National University School of Medicine, Daegu, South Korea.
12
Department of Neurology, Eulji General Hospital, Seoul, South Korea.
13
Department of Neurology, Soonchun Hyang University Hospital Cheonan, Cheonan, South Korea.
14
Department of Neurology, Kangwon National University Hospital, Chuncheon, South Korea.
15
Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.
16
Department of Psychiatry, Seoul National University Hospital, Seoul, South Korea.
17
Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
18
Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Department of Neurology, Seoul National University Hospital Healthcare System Gangnam Center, South Korea.
19
Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea; Protein Metabolism Research Center, Seoul National University College of Medicine, Seoul, South Korea.
20
Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: stemcell.snu@gmail.com.
21
Department of Neurology, Laboratory of Neurotherapeutics, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: sangkun2923@gmail.com.

Abstract

We aimed to evaluate the prevalence of antineuronal antibodies in a nationwide cohort of patients with encephalopathy of unknown etiology. We screened 1699 patients with idiopathic encephalopathy who were referred from 70 hospitals across Korea for autoimmune synaptic and classic paraneoplastic antibodies. Those with cerebellar degeneration, sensory polyneuropathy or other paraneoplastic syndromes without encephalopathy were not included in this study. One-hundred and four patients (6.12%) had antibody-associated autoimmune encephalopathy. Autoimmune synaptic antibodies were identified in 89 patients (5.24%) and classic paraneoplastic antibodies were identified in 16 patients (0.94%). The patients with antibody-associated autoimmune encephalopathy comprised a small but significant portion of the total number of patients with encephalopathy of unknown cause.

KEYWORDS:

Autoimmune; Autoimmune synaptic antibody; Classic paraneoplastic antibody; Encephalopathy; Prevalence

PMID:
27049559
DOI:
10.1016/j.jneuroim.2016.02.002
[Indexed for MEDLINE]

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