Decreased serum levels of T-cell immunoglobulin mucin-1 and T-cell immunoglobulin mucin-3 in systemic lupus erythematosus patients

J Biol Regul Homeost Agents. 2016 Jan-Mar;30(1):123-9.

Abstract

This study aims to investigate the serum T-cell immunoglobulin mucin (TIM)-1 and TIM-3 levels in systemic lupus erythematosus (SLE) patients and analyze their correlations with clinical features. Sixtyone SLE patients and 69 healthy controls were enrolled, serum TIM-1 and TIM-3 levels were detected by ELISA. Results demonstrated that both serum TIM-1 and TIM-3 levels were significantly decreased in SLE patients compared with controls (both P less than 0.05). Lower serum TIM-3 levels in SLE patients with nephritis were observed when compared to those without nephritis, with a marginal statistical significance (P=0.059). However, both serum TIM-1 and TIM-3 levels had no significant correlation with SLE disease activity (both >0.05). In summary, decreased serum TIM-1 and TIM-3 levels and association of TIM-3 with nephritis suggest their possible role in the development and pathogenesis of SLE. However, further studies are needed to confirm these preliminary results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Hepatitis A Virus Cellular Receptor 1
  • Hepatitis A Virus Cellular Receptor 2
  • Humans
  • Lupus Erythematosus, Systemic / blood*
  • Lupus Erythematosus, Systemic / pathology
  • Male
  • Membrane Glycoproteins / blood*
  • Membrane Proteins / blood*
  • Receptors, Virus / blood*

Substances

  • HAVCR1 protein, human
  • HAVCR2 protein, human
  • Hepatitis A Virus Cellular Receptor 1
  • Hepatitis A Virus Cellular Receptor 2
  • Membrane Glycoproteins
  • Membrane Proteins
  • Receptors, Virus