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J Biol Regul Homeost Agents. 2016 Jan-Mar;30(1):123-9.

Decreased serum levels of T-cell immunoglobulin mucin-1 and T-cell immunoglobulin mucin-3 in systemic lupus erythematosus patients.

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Department of Preventive Medicine, Wannan Medical College, Wuhu, Anhui, China.
School of Health Management, Anhui Medical University, Hefei, Anhui, China.
Department of Rheumatology and Immunology, the First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.


This study aims to investigate the serum T-cell immunoglobulin mucin (TIM)-1 and TIM-3 levels in systemic lupus erythematosus (SLE) patients and analyze their correlations with clinical features. Sixtyone SLE patients and 69 healthy controls were enrolled, serum TIM-1 and TIM-3 levels were detected by ELISA. Results demonstrated that both serum TIM-1 and TIM-3 levels were significantly decreased in SLE patients compared with controls (both P less than 0.05). Lower serum TIM-3 levels in SLE patients with nephritis were observed when compared to those without nephritis, with a marginal statistical significance (P=0.059). However, both serum TIM-1 and TIM-3 levels had no significant correlation with SLE disease activity (both >0.05). In summary, decreased serum TIM-1 and TIM-3 levels and association of TIM-3 with nephritis suggest their possible role in the development and pathogenesis of SLE. However, further studies are needed to confirm these preliminary results.

[Indexed for MEDLINE]

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