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J Biol Regul Homeost Agents. 2016 Jan-Mar;30(1):123-9.

Decreased serum levels of T-cell immunoglobulin mucin-1 and T-cell immunoglobulin mucin-3 in systemic lupus erythematosus patients.

Author information

1
Department of Preventive Medicine, Wannan Medical College, Wuhu, Anhui, China.
2
School of Health Management, Anhui Medical University, Hefei, Anhui, China.
3
Department of Rheumatology and Immunology, the First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui China.
4
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.

Abstract

This study aims to investigate the serum T-cell immunoglobulin mucin (TIM)-1 and TIM-3 levels in systemic lupus erythematosus (SLE) patients and analyze their correlations with clinical features. Sixtyone SLE patients and 69 healthy controls were enrolled, serum TIM-1 and TIM-3 levels were detected by ELISA. Results demonstrated that both serum TIM-1 and TIM-3 levels were significantly decreased in SLE patients compared with controls (both P less than 0.05). Lower serum TIM-3 levels in SLE patients with nephritis were observed when compared to those without nephritis, with a marginal statistical significance (P=0.059). However, both serum TIM-1 and TIM-3 levels had no significant correlation with SLE disease activity (both >0.05). In summary, decreased serum TIM-1 and TIM-3 levels and association of TIM-3 with nephritis suggest their possible role in the development and pathogenesis of SLE. However, further studies are needed to confirm these preliminary results.

PMID:
27049082
[Indexed for MEDLINE]

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