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Trends Parasitol. 2016 Jun;32(6):458-469. doi: 10.1016/j.pt.2016.03.002. Epub 2016 Apr 2.

Current Threat of Triclabendazole Resistance in Fasciola hepatica.

Author information

1
Department of Animal, Plant and Soil Sciences and Centre for AgriBioscience, La Trobe University, Bundoora, VIC, Australia.
2
Veterinary Health Research, Armidale, NSW, Australia.
3
Virbac (Australia) Pty Ltd, Milperra, NSW, Australia.
4
Moredun Research Institute, Pentlands Science Park, Bush Loan, Midlothian, UK.
5
Department of Animal, Plant and Soil Sciences and Centre for AgriBioscience, La Trobe University, Bundoora, VIC, Australia. Electronic address: t.spithill@latrobe.edu.au.

Abstract

Triclabendazole (TCBZ) is the only chemical that kills early immature and adult Fasciola hepatica (liver fluke) but widespread resistance to the drug greatly compromises fluke control in livestock and humans. The mode of action of TCBZ and mechanism(s) underlying parasite resistance to the drug are not known. Due to the high prevalence of TCBZ resistance (TCBZ-R), effective management of drug resistance is now critical for sustainable livestock production. Here, we discuss the current status of TCBZ-R in F. hepatica, the global distribution of resistance observed in livestock, the possible mechanism(s) of drug action, the proposed mechanisms and genetic basis of resistance, and the prospects for future control of liver fluke infections using an integrated parasite management (IPM) approach.

KEYWORDS:

Fasciola hepatica; cattle; liver fluke; resistance; sheep; triclabendazole

PMID:
27049013
DOI:
10.1016/j.pt.2016.03.002
[Indexed for MEDLINE]

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