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Eur Radiol. 2016 Dec;26(12):4465-4474. Epub 2016 Apr 5.

Software performance in segmenting ground-glass and solid components of subsolid nodules in pulmonary adenocarcinomas.

Author information

1
Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, Seoul National University Medical Research Center, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.
2
Clinique Universitaire de Radiologie et Imagerie Médicale (CURIM), Université Joseph Fourier, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043, Grenoble Cedex 9, France.
3
Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, Seoul National University Medical Research Center, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea. jmgoo@plaza.snu.ac.kr.
4
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. jmgoo@plaza.snu.ac.kr.
5
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
6
Department of Radiology and Nuclear Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands.
7
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
8
Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, Korea.

Abstract

OBJECTIVE:

To evaluate the performance of software in segmenting ground-glass and solid components of subsolid nodules in pulmonary adenocarcinomas.

METHOD:

Seventy-three pulmonary adenocarcinomas manifesting as subsolid nodules were included. Two radiologists measured the maximal axial diameter of the ground-glass components on lung windows and that of the solid components on lung and mediastinal windows. Nodules were segmented using software by applying five (-850 HU to -650 HU) and nine (-130 HU to -500 HU) attenuation thresholds. We compared the manual and software measurements of ground-glass and solid components with pathology measurements of tumour and invasive components.

RESULTS:

Segmentation of ground-glass components at a threshold of -750 HU yielded mean differences of +0.06 mm (p = 0.83, 95 % limits of agreement, 4.51 to 4.67) and -2.32 mm (p < 0.001, -8.27 to 3.63) when compared with pathology and manual measurements, respectively. For solid components, mean differences between the software (at -350 HU) and pathology measurements and between the manual (lung and mediastinal windows) and pathology measurements were -0.12 mm (p = 0.74, -5.73 to 5.55]), 0.15 mm (p = 0.73, -6.92 to 7.22), and -1.14 mm (p < 0.001, -7.93 to 5.64), respectively.

CONCLUSION:

Software segmentation of ground-glass and solid components in subsolid nodules showed no significant difference with pathology.

KEY POINTS:

• Software can effectively segment ground-glass and solid components in subsolid nodules. • Software measurements show no significant difference with pathology measurements. • Manual measurements are more accurate on lung windows than on mediastinal windows.

KEYWORDS:

Adenocarcinoma; Lung cancer; Segmentation; Solitary pulmonary nodule; Subsolid nodule

PMID:
27048527
DOI:
10.1007/s00330-016-4317-3
[Indexed for MEDLINE]

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