Format

Send to

Choose Destination
Autophagy. 2016;12(3):590-1. doi: 10.1080/15548627.2015.1125072.

The ins and outs of reticulocyte maturation revisited: The role of autophagy in sickle cell disease.

Author information

1
a Bristol Institute for Transfusion Sciences, NHS Blood and Transplant , Filton , Bristol , UK.
2
b Joint Red Cell Unit, University College London NHS Foundation Trust, Haematology Department , London , UK.

Abstract

Autophagy plays an important role in the removal of membrane bound organelles during the last stage of erythropoiesis as the enucleate reticulocyte matures into the erythrocyte. Autophagic vesicles are expelled from the reticulocyte as intact, inside-out, phosphatidylserine (PS) decorated vesicles and are subsequently removed during splenic passage. Failure to remove these vesicles causes the elevation in PS exposed red cells in Sickle Cell Disease.

PMID:
27046252
PMCID:
PMC4836018
DOI:
10.1080/15548627.2015.1125072
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center