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Bioarchitecture. 2016;6(2):39-45. doi: 10.1080/19490992.2016.1156284.

Ankyrin-B in lens architecture and biomechanics: Just not tethering but more.

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a Department of Ophthalmology , Duke University School of Medicine , Durham , NC , USA.
b Department of Pharmacology & Cancer Biology , Duke University School of Medicine , Durham , NC , USA.


The ankyrins are a family of well-characterized metazoan adaptor proteins that play a key role in linking various membrane-spanning proteins to the underlying spectrin-actin cytoskeleton; a mechanistic understanding of their role in tissue architecture and mechanics, however, remains elusive. Here we comment on a recent study demonstrating a key role for ankyrin-B in maintaining the hexagonal shape and radial alignment of ocular lens fiber cells by regulating the membrane organization of periaxin, dystrophins/dystroglycan, NrCAM and spectrin-actin network of proteins, and revealing that ankyrin-B deficiency impairs fiber cell shape and mechanical properties of the ocular lens. These observations indicate that ankyrin-B plays an important role in maintaining tissue cytoarchitecture, cell shape and biomechanical properties via engaging in key protein: protein interactions required for membrane anchoring and organization of the spectrin-actin skeleton, scaffolding proteins and cell adhesive proteins.


ankyrin-B; biomechanics; cell shape; cytoarchitecture; lens fibers; membrane organization

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