Format

Send to

Choose Destination
Biomed Pharmacother. 2016 Apr;79:153-8. doi: 10.1016/j.biopha.2016.01.011. Epub 2016 Feb 22.

miR-935 promotes gastric cancer cell proliferation by targeting SOX7.

Author information

1
The Second Department of Tumor Surgery, Cangzhou Central Hospital, Cangzhou, Hebei, China.
2
The Second Department of Tumor Surgery, Cangzhou Central Hospital, Cangzhou, Hebei, China. Electronic address: yangmeng20161770@qq.com.

Abstract

Gastric cancer is the most common cancer in the world, miRNAs have been demonstrated to play critical role in the development and progression of gastric cancer, such as miR-7, miR-217 and miR-335. Here, we found miR-935 was upregulated in gastric cancer tissues and cells. Overexpression of miR-935 promoted cell proliferation and tumorigenesis in vitro determined by MTT analysis, colony formation analysis, BrdU cell proliferation analysis and soft agar growth analysis, knockdown of miR-935 reduced these effects. Tumor suppressor sex-determining region Y-box 7 (SOX7) was the direct target of miR-935, overexpression of miR-935 inhibited SOX7 expression, but promoted the levels CCND1 and C-MYC which promotes cell proliferation and tumorigenesis, knockdown of miR-935 increased SOX7 level, and inhibited CCND1 and C-MYC expression. Synchronous knockdown of miR-935 and SOX7 promoted cell proliferation and tumorigenesis in vitro, confirming miR-935 regulated gastric cancer cell proliferation by inhibiting SOX7. In summary, we found miR-935 contributed to cell proliferation of gastric cancer through targeting SOX7.

KEYWORDS:

Cell proliferation; Gastric cancer; SOX7; miR-935

PMID:
27044823
DOI:
10.1016/j.biopha.2016.01.011
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center