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Blood. 2016 Jun 9;127(23):2809-13. doi: 10.1182/blood-2015-12-639112. Epub 2016 Apr 4.

Hepcidin in the diagnosis of iron disorders.

Author information

1
Section of Internal Medicine, Department of Medicine, University of Verona, Veneto Region Referral Center for Iron Metabolism Disorders, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy;
2
Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA; and.
3
Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center, Nijmegen, The Netherlands.

Abstract

The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our understanding of iron disorders, and its measurement should advance diagnosis/treatment of these conditions. Although several assays have been developed, a gold standard is still lacking, and efforts toward harmonization are ongoing. Nevertheless, promising applications can already be glimpsed, ranging from the use of hepcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications such as guiding safe iron supplementation in developing countries with high infection burden.

PMID:
27044621
PMCID:
PMC4956612
DOI:
10.1182/blood-2015-12-639112
[Indexed for MEDLINE]
Free PMC Article

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