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Inorg Chem. 2016 Apr 18;55(8):3718-20. doi: 10.1021/acs.inorgchem.6b00107. Epub 2016 Apr 4.

Tetra-Antimony(III)-Bridged 18-Tungsto-2-Arsenates(V), [(LSb(III))4(A-α-As(V)W9O34)2](10-) (L = Ph, OH): Turning Bioactivity On and Off by Ligand Substitution.

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Department of Life Sciences and Chemistry, Jacobs University , P.O. Box 750 561, 28725 Bremen, Germany.
Department of Chemistry, Faculty of Sciences, University of Balamand , P.O. Box 100, Tripoli, Lebanon.
Department of Chemistry, College of Sciences, Shanghai University , Shanghai 200444, People's Republic of China.
Department of Chemistry, Supramolecular Organic and Organometallic Chemistry Centre (SOOMCC), Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University , RO-400028 Cluj-Napoca, Romania.


Two tetra-antimony(III)-bridged, sandwich-type 18-tungsto-2-arsenates(V), [(LSb(III))4(A-α-As(V)W9O34)2](10-) (L = Ph (1), OH (2)), were prepared and fully characterized in the solid state and in solution. Both polyanions are stable in aqueous physiological medium for at least 24 h (at concentrations ≥2.5 × 10(-6) M). Despite the presence of an isostructural tetra-antimony(III) motif in 1 and 2, distinctly different antibacterial activity was observed for both polyanions. The minimum inhibitory concentrations (MIC) of 1 (7.8-62.5 μg/mL) is lower than for any other organoantimony(III)-containing polyoxometalate reported to date.

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