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J Health Commun. 2016;21 Suppl 1:5-17. doi: 10.1080/10810730.2015.1131772.

Guiding Oncology Patients Through the Maze of Precision Medicine.

Author information

1
a Knowledge Management , Vanderbilt University Medical Center , Nashville , Tennessee , USA.
2
b Department of Biomedical Informatics , Vanderbilt University Medical Center , Nashville , Tennessee , USA.
3
c Department of Medicine , Vanderbilt University School of Medicine , Nashville , Tennessee , USA.
4
d Center for Quantitative Sciences , Vanderbilt University School of Medicine , Nashville , Tennessee , USA.
5
e Vanderbilt-Ingram Cancer Center , Nashville , Tennessee , USA.
6
f Department of Medicine, Division of Hematology/Oncology , Vanderbilt University Medical Center , Nashville , Tennessee , USA.
7
g Cancer Clinical Informatics , Vanderbilt-Ingram Cancer Center , Nashville , Tennessee , USA.
8
h Department of Biostatistics , Vanderbilt University School of Medicine , Nashville , Tennessee , USA.
9
i Department of Cancer Biology , Vanderbilt University School of Medicine , Nashville , Tennessee , USA.

Abstract

As the role of genomics in health care grows, patients increasingly require adequate genetic literacy to fully engage in their care. This study investigated a model for delivering consumer-friendly genetic information to improve understanding of precision medicine using health literacy and learning style principles. My Cancer Genome (MCG), a freely available cancer decision support tool, was used as a testbed. MCG content on a melanoma tumor mutation, BRAF V600E, was translated to a 6th-grade reading level, incorporating multiple learning modalities. A total of 90 patients and caregivers were recruited from a melanoma clinic at an academic medical center and randomized to 3 groups. Group A (control) received an exact copy of text from MCG. Group B was given the same content with hyperlinks to videos explaining key genetic concepts, identified and labeled by the team as knowledge pearls. Group C received the translated content with the knowledge pearls embedded. Changes in knowledge were measured through pre and post questionnaires. Group C showed the greatest improvement in knowledge. The study results demonstrate that providing information based on health literacy and learning style principles can improve patients' understanding of genetic concepts, thus increasing their likelihood of taking an active role in any decision making concerning their health.

PMID:
27043753
PMCID:
PMC4910693
DOI:
10.1080/10810730.2015.1131772
[Indexed for MEDLINE]
Free PMC Article

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