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Expert Opin Ther Pat. 2016 May;26(5):607-16. doi: 10.1517/13543776.2016.1170810. Epub 2016 Apr 6.

Dual leucine zipper kinase (MAP3K12) modulators: a patent review (2010-2015).

Author information

1
a Department of Clinical Pharmacology and Toxicology , University Medical Center Hamburg-Eppendorf , Hamburg , Germany.
2
b DZHK Partner-site Hamburg/Kiel/Luebeck , Germany.
3
c Institute of Pharmacy , University of Hamburg , Hamburg , Germany.

Abstract

INTRODUCTION:

The dual leucine zipper kinase (DLK, MAP3K12) is essential for neuronal development and has been shown to mediate axon regeneration. On the other hand, DLK is involved in the pathogenesis of neurodegenerative disease and diabetes mellitus. Several patents have been published claiming to modulate or inhibit DLK by various approaches including ATP competitive inhibitors. In addition, two publications describe SAR of highly selective DLK inhibitors with efficacy in distinct mouse models of neurodegeneration.

AREAS COVERED:

This review summarized patents claiming to modulate DLK activity published between 2010 and 2015. Peer-reviewed publications related to the patents and additional peer-reviewed publications are included. This article describes 18 patents from three pharmaceutical companies and three academic research groups.

EXPERT OPINION:

Several methods are proposed to modulate DLK activity, some of them very experimental and not suitable for easy application in patients. ATP competitive kinase inhibitors exert high affinity, but for the majority, no information about their selectivity is available. To date, two inhibitors have been tested in mice. Given the controversial findings that DLK is required for neurodegeneration and for axon regeneration, more research is needed to further elucidate the regulation and the function of this kinase in diverse organs/tissues and under physiological and pathological conditions.

KEYWORDS:

Axon regeneration; diabetes mellitus type 2; dual leucine zipper kinase; mitogen-activated kinases; mixed lineage kinase; neurodegeneration

PMID:
27043251
DOI:
10.1517/13543776.2016.1170810
[Indexed for MEDLINE]

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