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J Stroke Cerebrovasc Dis. 2016 Jun;25(6):1503-8. doi: 10.1016/j.jstrokecerebrovasdis.2016.02.034. Epub 2016 Mar 30.

Protocol of the Stroke in Korean Young Adults Study: A Multicenter Case-Control Study and Prospective Cohort Study.

Author information

1
Department of Neurology, Hanyang University College of Medicine, Seoul, Republic of Korea.
2
Department of Neurology, Hallym University Sacred Heart Hospital, Chuncheon, Republic of Korea.
3
Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea.
4
Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
5
Department of Neurology, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
6
Department of Neurology, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
7
Department of Neurology and Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
8
Department of Neurology, Chung-Ang University Hospital, Seoul, Republic of Korea.
9
Department of Neurology, Hanyang University College of Medicine, Seoul, Republic of Korea. Electronic address: aescula@hanmail.net.

Abstract

BACKGROUND:

The incidence of ischemic stroke in young adults has been rising over recent decades, but there is still limited information on its risk factors, etiologies, and outcomes. Because these patients generally participate in social life, risk factors associated with lifestyle may have a great impact and need to be identified.

METHODS:

The SKY (Stroke in Korean Young Adults) study is a multicenter case-control study and a prospective cohort study in 8 tertiary medical centers in the Republic of Korea. The case subjects are patients aged 18-44 years with first-ever ischemic stroke occurring within 1 month of stroke onset, and the control subjects are age- and gender-matched community controls. Our aim is to include 470 cases and 470 controls. The main objective of our study is to determine the risk factors and the causes of ischemic stroke in Korean young adults. Both well-documented risk factors and little-known lifestyle-related risk factors such as lifestyle habits and psychological distress including job strain will be evaluated by comparing cases and controls using a structured questionnaire. Secondary objectives are to determine the risks of mortality, recurrent vascular events, and poststroke epilepsy in these patients. Conditional logistic regression analysis will be used to estimate odds ratios and 95% confidence intervals.

CONCLUSIONS:

The SKY study is designed to obtain more insights into relatively little-known risk factors in young Korean adults with ischemic stroke. The results may also help identify the frequencies of uncommon etiologies and outcomes in these patients.

KEYWORDS:

Stroke etiology; psychological distress; risk factors; stroke outcome; young patients

[Indexed for MEDLINE]

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