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Scand J Med Sci Sports. 2017 Jul;27(7):704-713. doi: 10.1111/sms.12685. Epub 2016 Mar 31.

Live high, train low - influence on resting and post-exercise hepcidin levels.

Author information

1
Institute for Sport & Physical Activity Research, University of Bedfordshire, Bedford, UK.
2
School of Sport Science, Exercise & Health, University of Western Australia, Crawley, Western Australia, Australia.
3
Centre for Exercise & Sports Science Research, School of Exercise and Health Science, Edith Cowan University, Joondalup, Western Australia, Australia.
4
School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia.
5
Department of Laboratory Medicine (TML 830), Radboud University Medical Centre, Nijmegen, The Netherlands.
6
Hepcidinanalysis.com, Radboudumc, Geert Grooteplein 10 (TML 830), Nijmegen, The Netherlands.
7
Research Institute for Sport & Exercise, University of Canberra, Belconnen, Australian Capital Territory, Australia.
8
Department of Physiology, Australian Institute of Sport, Bruce, Australian Capital Territory, Australia.
9
Exercise Physiology Laboratory, Flinders University, Bedford Park, South Australia, Australia.

Abstract

The post-exercise hepcidin response during prolonged (>2 weeks) hypoxic exposure is not well understood. We compared plasma hepcidin levels 3 h after exercise [6 × 1000 m at 90% of maximal aerobic running velocity (vVO2max )] performed in normoxia and normobaric hypoxia (3000 m simulate altitude) 1 week before, and during 14 days of normobaric hypoxia [196.2 ± 25.6 h (median: 200.8 h; range: 154.3-234.8 h) at 3000 m simulated altitude] in 10 well-trained distance runners (six males, four females). Venous blood was also analyzed for hepcidin after 2 days of normobaric hypoxia. Hemoglobin mass (Hbmass ) was measured via CO rebreathing 1 week before and after 14 days of hypoxia. Hepcidin was suppressed after 2 (Cohen's d = -2.3, 95% confidence interval: [-2.9, -1.6]) and 14 days of normobaric hypoxia (d = -1.6 [-2.6, -0.6]). Hepcidin increased from baseline, 3 h post-exercise in normoxia (d = 0.8 [0.2, 1.3]) and hypoxia (d = 0.6 [0.3, 1.0]), both before and after exposure (normoxia: d = 0.7 [0.3, 1.2]; hypoxia: d = 1.3 [0.4, 2.3]). In conclusion, 2 weeks of normobaric hypoxia suppressed resting hepcidin levels, but did not alter the post-exercise response in either normoxia or hypoxia, compared with the pre-exposure response.

KEYWORDS:

Iron metabolism; altitude training; hypoxia; iron deficiency

PMID:
27038097
DOI:
10.1111/sms.12685
[Indexed for MEDLINE]

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