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Development. 2016 May 15;143(10):1753-65. doi: 10.1242/dev.131102. Epub 2016 Mar 31.

Molecular control of two novel migratory paths for CGE-derived interneurons in the developing mouse brain.

Author information

1
Univ. Nice Sophia Antipolis, INSERM U1091, CNRS UMR7277, iBV, Nice 06100, France iBV, Institut de Biologie Valrose, Univ. Sophia Antipolis, Bâtiment Sciences Naturelles; UFR Sciences; Parc Valrose, 28, avenue Valrose, Nice Cedex 2 06108, France.
2
Univ. Nice Sophia Antipolis, INSERM U1091, CNRS UMR7277, iBV, Nice 06100, France iBV, Institut de Biologie Valrose, Univ. Sophia Antipolis, Bâtiment Sciences Naturelles; UFR Sciences; Parc Valrose, 28, avenue Valrose, Nice Cedex 2 06108, France Instituto de Neurociencias de Alicante (Consejo Superior de Investigaciones Cientificas-Universidad Miguel Hernandez, CSIC-UMH), Aliante 03550, Spain.
3
Inserm U1141 PROTECT, Hôpital Robert-Debré, Paris 75019, France.
4
Univ. Nice Sophia Antipolis, INSERM U1091, CNRS UMR7277, iBV, Nice 06100, France iBV, Institut de Biologie Valrose, Univ. Sophia Antipolis, Bâtiment Sciences Naturelles; UFR Sciences; Parc Valrose, 28, avenue Valrose, Nice Cedex 2 06108, France michele.studer@unice.fr.

Abstract

GABAergic interneurons are highly heterogeneous and originate in the subpallium mainly from the medial (MGE) and caudal (CGE) ganglionic eminences according to a precise temporal sequence. MGE-derived cells disperse dorsally and migrate towards all regions of the cortex, but little is known about how CGE-derived cells reach their targets during development. Here, we unravel the existence of two novel CGE caudo-rostral migratory streams, one located laterally (LMS) and the other one more medially (MMS), that, together with the well-known caudal migratory stream (CMS), contribute to populate the neocortex, hippocampus and amygdala. These paths appear in a precise temporal sequence and express a distinct combination of transcription factors, such as SP8, PROX1, COUP-TFI and COUP-TFII. By inactivating COUP-TFI in developing interneurons, the lateral and medial streams are perturbed and expression of SP8 and COUP-TFII affected. As a consequence, adult mutant neocortices have laminar-specific alterations of distinct cortical interneuron subtypes. Overall, we propose that the existence of spatially and temporally regulated migratory paths in the subpallium contributes to the laminar distribution and specification of distinct interneuron subpopulations in the adult brain.

KEYWORDS:

5HT3aR; COUP-TFI; COUP-TFII; Caudal ganglionic eminence; Development; Interneuron migration; Mouse brain; PROX1; SP8

PMID:
27034423
DOI:
10.1242/dev.131102
[Indexed for MEDLINE]
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