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J Cell Sci. 2017 Jan 1;130(1):97-103. doi: 10.1242/jcs.179952. Epub 2016 Mar 31.

Myosin II governs collective cell migration behaviour downstream of guidance receptor signalling.

Author information

1
LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 31062 Toulouse, France.
2
DamCB, Data Analysis and Modelling for Cell Biology, Marseille F-13005, France.
3
INSERM, UMR 1043, Centre de Physiopathologie de Toulouse Purpan, 31024 Toulouse, France.
4
Université Toulouse III Paul-Sabatier, 31062 Toulouse, France.
5
CNRS, UMR 5282, 31204 Toulouse, France.
6
LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 31062 Toulouse, France xiaobo.wang@univ-tlse3.fr.

Abstract

Border cell migration during Drosophila oogenesis is a potent model to study collective cell migration, a process involved in development and metastasis. Border cell clusters adopt two main types of behaviour during migration: linear and rotational. However, the molecular mechanism controlling the switch from one to the other is unknown. Here, we demonstrate that non-muscle Myosin II (NMII, also known as Spaghetti squash) activity controls the linear-to-rotational switch. Furthermore, we show that the regulation of NMII takes place downstream of guidance receptor signalling and is critical to ensure efficient collective migration. This study thus provides new insight into the molecular mechanism coordinating the different cell behaviours in a migrating cluster.

KEYWORDS:

Border cells; Collective cell migration; Guidance receptor; Myosin II

PMID:
27034137
DOI:
10.1242/jcs.179952
[Indexed for MEDLINE]
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