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FASEB J. 2016 Jul;30(7):2541-8. doi: 10.1096/fj.201500018R. Epub 2016 Mar 31.

Maternal exercise during pregnancy promotes physical activity in adult offspring.

Author information

1
U.S. Department of Agriculture/Agricultural Research Service (USDA/ARS) Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA;
2
Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas USA; and.
3
U.S. Department of Agriculture/Agricultural Research Service (USDA/ARS) Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA waterland@bcm.edu.

Abstract

Previous rodent studies have shown that maternal voluntary exercise during pregnancy leads to metabolic changes in adult offspring. We set out to test whether maternal voluntary exercise during pregnancy also induces persistent changes in voluntary physical activity in the offspring. Adult C57BL/6J female mice were randomly assigned to be caged with an unlocked (U) or locked (L) running wheel before and during pregnancy. Maternal running behavior was monitored during pregnancy, and body weight, body composition, food intake, energy expenditure, total cage activity, and running wheel activity were measured in the offspring at various ages. U offspring were slightly heavier at birth, but no group differences in body weight or composition were observed at later ages (when mice were caged without access to running wheels). Consistent with our hypothesis, U offspring were more physically active as adults. This effect was observed earlier in female offspring (at sexual maturation). Remarkably, at 300 d of age, U females achieved greater fat loss in response to a 3-wk voluntary exercise program. Our findings show for the first time that maternal physical activity during pregnancy affects the offspring's lifelong propensity for physical activity and may have important implications for combating the worldwide epidemic of physical inactivity and obesity.-Eclarinal, J. D., Zhu, S., Baker, M. S., Piyarathna, D. B., Coarfa, C., Fiorotto, M. L., Waterland, R. A. Maternal exercise during pregnancy promotes physical activity in adult offspring.

KEYWORDS:

activity-stat; developmental programming; metabolic imprinting

PMID:
27033262
PMCID:
PMC4904289
DOI:
10.1096/fj.201500018R
[Indexed for MEDLINE]
Free PMC Article

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