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Semin Cell Dev Biol. 2016 Sep;57:93-99. doi: 10.1016/j.semcdb.2016.03.017. Epub 2016 Mar 23.

Virulence-specific cell cycle and morphogenesis connections in pathogenic fungi.

Author information

1
Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas, Salamanca, Spain. Electronic address: jose.perez@csic.es.
2
Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas, Salamanca, Spain.

Abstract

To initiate pathogenic development, pathogenic fungi respond to a set of inductive cues. Some of them are of an extracellular nature (environmental signals), while others are intracellular (developmental signals). These signals must be integrated into a single response whose major outcome is changes in the morphogenesis of the fungus. The regulation of the cell cycle is pivotal during these cellular differentiation steps; therefore, cell cycle regulation would likely provide control points for infectious development by fungal pathogens. Here, we provide clues to understanding how the control of the cell cycle is integrated with the morphogenesis program in pathogenic fungi, and we review current examples that support these connections.

KEYWORDS:

Appressorium; Candida albicans; Cell cycle; Fungal virulence; Magnaporthe oryzae; Ustilago maydis

PMID:
27032479
DOI:
10.1016/j.semcdb.2016.03.017
[Indexed for MEDLINE]

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