Format

Send to

Choose Destination
See comment in PubMed Commons below
J Vet Sci. 2016 Dec 30;17(4):435-444. doi: 10.4142/jvs.2016.17.4.435.

Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model.

Author information

  • 1Laboratory of Radiation Exposure & Therapeutics, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul 01812, Korea.
  • 2Research Center, Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Busan 46033, Korea.
  • 3Department of Dermatology, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul 01812, Korea.
  • 4College of Oriental Medicine, Dongshin Univiersity, Naju 58245, Korea.

Abstract

Curcumin protects the skin against radiation-induced epidermal damage and prevents morphological changes induced by irradiation skin, thereby maintaining the epidermal thickness and cell density of basal layers. In this study, the effects of topical curcumin treatment on radiation burns were evaluated in a mini-pig model. Histological and clinical changes were observed five weeks after radiation exposure to the back (⁶⁰Co gamma-radiation, 50 Gy). Curcumin was applied topically to irradiated skin (200 mg/cm²) twice a day for 35 days. Curcumin application decreased the epithelial desquamation after irradiation. Additionally, when compared to the vehicle-treated group, the curcumin-treated group showed reduced expression of cyclooxygenase-2 and nuclear factor-kappaB. Furthermore, irradiation prolonged healing of biopsy wounds in the exposed area, whereas curcumin treatment stimulated wound healing. These results suggest that curcumin can improve epithelial cell survival and recovery in the skin and therefore be used to treat radiation burns.

KEYWORDS:

curcumin; mini-pig; radiation burns; skin

PMID:
27030193
PMCID:
PMC5204020
DOI:
10.4142/jvs.2016.17.4.435
[PubMed - in process]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for The Korean Society of Veterinary Science Icon for PubMed Central
    Loading ...
    Support Center