Format

Send to

Choose Destination
J Hum Genet. 2016 Jul;61(7):593-603. doi: 10.1038/jhg.2016.26. Epub 2016 Mar 31.

New native South American Y chromosome lineages.

Author information

1
Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
2
Instituto de Genética y Biología Molecular, Universidad San Martin de Porres, Lima, Peru.
3
Facultad de Bioquímica, Universidad Mayor de San Andrés, La Paz, Bolivia.
4
Instituto de Investigaciones Biomédicas, Universidad de las Americas, Quito, Ecuador.
5
Universidad del Tolima, Ibagué, Colombia.
6
Department of Anthropology, University of Pennsylvania, Philadelphia, PA, USA.
7
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
8
The Wellcome Trust Sanger Institute, Hinxton, UK.

Abstract

Many single-nucleotide polymorphisms (SNPs) in the non-recombining region of the human Y chromosome have been described in the last decade. High-coverage sequencing has helped to characterize new SNPs, which has in turn increased the level of detail in paternal phylogenies. However, these paternal lineages still provide insufficient information on population history and demography, especially for Native Americans. The present study aimed to identify informative paternal sublineages derived from the main founder lineage of the Americas-haplogroup Q-L54-in a sample of 1841 native South Americans. For this purpose, we used a Y-chromosomal genotyping multiplex platform and conventional genotyping methods to validate 34 new SNPs that were identified in the present study by sequencing, together with many Y-SNPs previously described in the literature. We updated the haplogroup Q phylogeny and identified two new Q-M3 and three new Q-L54*(xM3) sublineages defined by five informative SNPs, designated SA04, SA05, SA02, SA03 and SA29. Within the Q-M3, sublineage Q-SA04 was mostly found in individuals from ethnic groups belonging to the Tukanoan linguistic family in the northwest Amazon, whereas sublineage Q-SA05 was found in Peruvian and Bolivian Amazon ethnic groups. Within Q-L54*, the derived sublineages Q-SA03 and Q-SA02 were exclusively found among Coyaima individuals (Cariban linguistic family) from Colombia, while Q-SA29 was found only in Maxacali individuals (Jean linguistic family) from southeast Brazil. Furthermore, we validated the usefulness of several published SNPs among indigenous South Americans. This new Y chromosome haplogroup Q phylogeny offers an informative paternal genealogy to investigate the pre-Columbian history of South America.Journal of Human Genetics advance online publication, 31 March 2016; doi:10.1038/jhg.2016.26.

PMID:
27030145
DOI:
10.1038/jhg.2016.26
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center