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J Endocrinol. 2016 Jun;229(3):233-43. doi: 10.1530/JOE-16-0040. Epub 2016 Mar 30.

The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling.

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Department of NeuroscienceFunctional Pharmacology, Uppsala University, Uppsala, Sweden
Department of NeuroscienceFunctional Pharmacology, Uppsala University, Uppsala, Sweden.


Transmembrane protein 18 (TMEM18) is an ill-described, obesity-related gene, but few studies have explored its molecular function. We found single-nucleotide polymorphism data, suggesting that TMEM18 may be involved in the regulation/physiology of metabolic syndrome based on associations with insulin, homeostatic model assessment-β (HOMAβ), triglycerides, and blood sugar. We then found an ortholog in the Drosophila genome, knocked down Drosophila Tmem18 specifically in insulin-producing cells, and tested for its effects on metabolic function. Our results suggest that TMEM18 affects substrate levels through insulin and glucagon signaling, and its downregulation induces a metabolic state resembling type 2 diabetes. This work is the first to experimentally describe the metabolic consequences of TMEM18 knockdown, and further supports its association with obesity.


AKH; CG30051; Drosophila; SNP; TMEM18; fly; glucagon; insulin; obesity

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