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Adv Mater. 2016 Jul;28(27):5381-99. doi: 10.1002/adma.201503986. Epub 2016 Mar 30.

Progress in Corneal Stromal Repair: From Tissue Grafts and Biomaterials to Modular Supramolecular Tissue-Like Assemblies.

Author information

1
Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
2
Center for Research in Medical Devices (CÚRAM), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.

Abstract

Corneal injuries and degenerative conditions have major socioeconomic consequences, given that in most cases, they result in blindness. In the quest of the ideal therapy, tissue grafts, biomaterials, and modular engineering approaches are under intense investigation. Herein, advancements and shortfalls are reviewed and future perspectives for these therapeutic strategies discussed.

KEYWORDS:

biomaterials; corneal keratocytes; corneal stromal; modular engineering; tissue grafts

PMID:
27028373
DOI:
10.1002/adma.201503986

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