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Biomarkers. 2016 Sep;21(6):509-16. doi: 10.3109/1354750X.2016.1160290. Epub 2016 Mar 30.

Monocyte subsets and monocyte-platelet aggregates: implications in predicting septic mortality among surgical critical illness patients.

Author information

1
a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , China.

Abstract

BACKGROUND:

Monocyte subsets and monocyte-platelet aggregates (MPAs) play important roles in inflammation.

AIM:

To evaluate the association between the three human monocyte subsets and their contributions to MPAs and mortality among septic patients.

METHODS:

Consecutive septic patients were enrolled in. Age- and gender-matched nonseptic patients were recruited as control patients. Monocyte subsets and monocyte-platelet aggregates were determined by flow cytometric analysis.

RESULTS:

Elevated percentage of MPAs (MPAs%) was associated with an increased risk of mortality.

CONCLUSIONS:

This study demonstrated increased MPAs% enables the identification of a group of septic patients at high risk of death.

KEYWORDS:

Monocyte subset; monocyte–platelet aggregates; mortality; sepsis

PMID:
27028194
DOI:
10.3109/1354750X.2016.1160290
[Indexed for MEDLINE]

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