Background: Monocyte subsets and monocyte-platelet aggregates (MPAs) play important roles in inflammation.
Aim: To evaluate the association between the three human monocyte subsets and their contributions to MPAs and mortality among septic patients.
Methods: Consecutive septic patients were enrolled in. Age- and gender-matched nonseptic patients were recruited as control patients. Monocyte subsets and monocyte-platelet aggregates were determined by flow cytometric analysis.
Results: Elevated percentage of MPAs (MPAs%) was associated with an increased risk of mortality.
Conclusions: This study demonstrated increased MPAs% enables the identification of a group of septic patients at high risk of death.
Keywords: Monocyte subset; monocyte–platelet aggregates; mortality; sepsis.