Oncotarget. 2017 May 9;8(19):30830-30843. doi: 10.18632/oncotarget.8306.

Prediction of mycoplasma hominis proteins targeting in mitochondria and cytoplasm of host cells and their implication in prostate cancer etiology.

Khan S^1,², Zakariah M³, Rolfo C⁴, Robrecht L⁴, Palaniappan S⁵.

Author information

1: Nanomedicine & Biotechnology Research Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
2: Department of Bioscience, Shri Ram Group of College (SRGC), Muzaffarnagar, India.
3: Research Center, College of Computer and Information Science, King Saud University, Riyadh, Saudi Arabia.
4: Phase I- Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital, "Centre for Oncological Research (CORE)", Edegem, Belgium.
5: School of Science and Engineeringing, Malaysia University of Science and Technology, Selangor, Malaysia.

Abstract

Although the idea of bacteria causing different types of cancer has exploded about century ago, the potential mechanisms of carcinogenesis is still not well established. Many reports showed the involvement of M. hominis in the development of prostate cancer, however, mechanistic approach for growth and development of prostate cancer has been poorly understood. In the current study, we predicted M. hominis proteins targeting in the mitochondria and cytoplasm of host cells and their implication in prostate cancer. A total of 77 and 320 proteins from M. hominis proteome were predicted to target in the mitochondria and cytoplasm of host cells respectively. In particular, various targeted proteins may interfere with normal growth behaviour of host cells, thereby altering the decision of programmed cell death. Furthermore, we investigated possible mechanisms of the mitochondrial and cytoplasmic targeted proteins of M. hominis in etiology of prostate cancer by screening the whole proteome.