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Neuroscience. 2016 Jun 14;325:124-31. doi: 10.1016/j.neuroscience.2016.03.051. Epub 2016 Mar 26.

Analysis of genetics and risk factors of Alzheimer's Disease.

Author information

1
Department of Neurology, Gazi University Faculty of Medicine, Ankara, Turkey. Electronic address: muefhulkika@gmail.com.
2
Department of Neurology, Gazi University Faculty of Medicine, Ankara, Turkey. Electronic address: ykaraman@gazi.edu.tr.
3
Department of Medical Genetics, Gazi University Faculty of Medicine, Ankara, Turkey. Electronic address: nsezenguntekin@yahoo.com.
4
Department of Medical Genetics, Gazi University Faculty of Medicine, Ankara, Turkey. Electronic address: maliergun@gmail.com.

Abstract

Alzheimer's Disease is the leading neurodegenerative cause of dementia. The pathogenesis is not clearly understood yet, is believed to be the complex interaction between genetic and environmental factors. Consequently vascular risk factors and Apolipoprotein E genotyping are increasingly gaining importance. This study aimed at assessing the relationships between Alzheimer's Disease and Apolipoprotein E phenotype and vascular risk factors. Patients diagnosed with "possible Alzheimer's Disease" in the Gazi University, Department of Neurology, were included in the study and age-matched volunteer patients who attended the polyclinic were included as a control group. In this study, the risk factors including low education level, smoking, hyperlipidemia, higher serum total cholesterol levels, and hyperhomocysteinemia were found to be statistically significantly more common in the Alzheimer's Disease group in comparison to the Control Group, while all Apolipoprotein E ε4/ε4 genotypes were found in the Alzheimer's Disease group. The presence of the Apolipoprotein E ε4 allele is believed to increase vascular risk factors as well as to affect Alzheimer's Disease directly. The biological indicators which are used in identifying the patients' genes will be probably used in the treatment plan of the patients in the future.

KEYWORDS:

Alzheimer’s Disease; Apolipoprotein E genotyping; biological indicators; dementia; vascular risk factors

[Indexed for MEDLINE]

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