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Cytokine Growth Factor Rev. 2016 Jun;29:109-15. doi: 10.1016/j.cytogfr.2016.02.006. Epub 2016 Mar 15.

Monocyte and interferon based therapy for the treatment of ovarian cancer.

Author information

1
Cytokine Biology Section, National Institute of Allergy and Infectious Diseases, National Institute of Health, USA. Electronic address: Daniel.green2@nih.gov.
2
Medical Oncology Branch, NCI, 10 Center DR, RM 12N226, Bethesda, MD 20814, USA. Electronic address: ana.nunes@nih.gov.
3
Women's Malignancy Branch, NCI, NIH, Translational Genomics Section, 10 Center DR RM 3B43A, Bethesda, MD 20892, USA. Electronic address: ca180n@nih.gov.
4
Cytokine Biology Section, National Institute of Allergy and Infectious Diseases, National Institute of Health, USA. Electronic address: kz15m@nih.gov.

Abstract

Cytokines and cells of the innate immune system have been shown to be critical regulators in the elimination, equilibrium and escape of malignant cells. Despite in vitro and in vivo evidence, components of the innate immune system have shown limited efficacy in the treatment of ovarian cancer. Intraperitoneal immunotherapies are a promising field that has not yet been fully explored in ovarian cancer. Cytokine immunotherapy using interferon alpha (IFN-α) and interferon gamma (IFN-γ) has predominantly been used intraperitoneally in ovarian cancer, with promising results. Early studies also showed that autologous monocytes infused into the peritoneum have anti-tumor properties. Combination therapies have been shown to be more effective in treating cancer than mono-therapies. Based on these observations the combination of cell therapy with cytokine therapy may provide a unique strategy for the treatment of chemotherapy resistant solid cancers.

KEYWORDS:

Immunotherapy; Interferon alpha; Interferon gamma; Monocyte; Ovarian cancer

PMID:
27026228
PMCID:
PMC4899185
DOI:
10.1016/j.cytogfr.2016.02.006
[Indexed for MEDLINE]
Free PMC Article

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