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J Neurol. 2016 Jun;263(6):1241-54. doi: 10.1007/s00415-016-8091-6. Epub 2016 Mar 30.

Recent advances in amyotrophic lateral sclerosis.

Author information

1
Neuropathology Unit, INSPE and Division of Neuroscience, Department of Neurology, Institute of Experimental Neurology, San Raffaele Scientific Institute, Via Olgettina 48, 20132, Milan, Italy. riva.nilo@hsr.it.
2
Neuroimaging Research Unit, Division of Neuroscience, Department of Neurology, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.
3
NEuroMuscular Omnicentre (NEMO), Niguarda Ca Granda Hospital, Milan, Italy.
4
Neuropathology Unit, INSPE and Division of Neuroscience, Department of Neurology, Institute of Experimental Neurology, San Raffaele Scientific Institute, Via Olgettina 48, 20132, Milan, Italy.

Abstract

ALS is a relentlessly progressive and fatal disease, with no curative therapies available to date. Symptomatic and palliative care, provided in a multidisciplinary context, still remains the cornerstone of ALS management. However, our understanding of the molecular mechanisms underlying the disease has advanced greatly over the past years, giving new hope for the development of novel diagnostic and therapeutic approaches. Here, we have reviewed the most recent studies that have contributed to improving both clinical management and our understanding of ALS pathogenesis.

KEYWORDS:

ALS genetics; Clinical management; Motor neuron disease; Neuroimaging; Pathogenesis

PMID:
27025851
PMCID:
PMC4893385
DOI:
10.1007/s00415-016-8091-6
[Indexed for MEDLINE]
Free PMC Article

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