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Pharmacol Res. 2016 May;107:234-242. doi: 10.1016/j.phrs.2016.03.026. Epub 2016 Mar 26.

Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials.

Author information

1
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
2
Medicine and Surgery Sciences Dept.,University of Bologna, Italy. Electronic address: arrigo.cicero@unibo.it.
3
Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico.
4
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX USA.
5
Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, India.

Abstract

BACKGROUND:

Tumor necrosis factor-α (TNF-α) is a key inflammatory mediator and its reduction is a therapeutic target in several inflammatory diseases. Curcumin, a bioactive polyphenol from turmeric, has been shown in several preclinical studies to block TNF-α effectively. However, clinical evidence has not been fully conclusive.

OBJECTIVE:

The aim of the present meta-analysis was to evaluate the efficacy of curcumin supplementation on circulating levels of TNF-α in randomized controlled trials (RCTs).

METHODS:

The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases by up to September 21, 2015, to identify RCTs investigating the impact of curcumin on circulating TNF-α concentration. Quantitative data synthesis was performed using a random-effects model, with weighed mean difference (WMD) and 95% confidence interval (CI) as summary statistics. Meta-regression and leave-one-out sensitivity analyses were performed to assess the modifiers of treatment response.

RESULTS:

Eight RCTs comprising nine treatment arms were finally selected for the meta-analysis. There was a significant reduction of circulating TNF-α concentrations following curcumin supplementation (WMD: -4.69pg/mL, 95% CI: -7.10, -2.28, p<0.001). This effect size was robust in sensitivity analysis. Meta-regression did not suggest any significant association between the circulating TNF-α-lowering effects of curcumin with either dose or duration (slope: 0.197; 95% CI: -1.73, 2.12; p=0.841) of treatment.

CONCLUSION:

This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating TNF-α concentration.

KEYWORDS:

Curcuma longa; Curcumin; Inflammation; Meta-analysis; Randomized controlled trial; TNF-α

PMID:
27025786
DOI:
10.1016/j.phrs.2016.03.026
[Indexed for MEDLINE]

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