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Crit Rev Biotechnol. 2017 May;37(3):333-354. doi: 10.3109/07388551.2016.1163321. Epub 2016 Mar 29.

Bioprinting: an assessment based on manufacturing readiness levels.

Wu C1,2, Wang B1,2,3, Zhang C1,3, Wysk RA4, Chen YW5,6.

Author information

1
a Georgia Tech Manufacturing Institute, Georgia Institute of Technology , Atlanta , GA , USA.
2
b School of Materials Science and Engineering , Georgia Institute of Technology , Atlanta , GA , USA.
3
c School of Industrial and Systems Engineering , Georgia Institute of Technology , Atlanta , GA , USA.
4
d Department of Industrial and Systems Engineering , North Carolina State University , Raleigh , NC , USA.
5
e Institute of Clinical Medical Science, China Medical University , Taichung , Taiwan , ROC.
6
f 3D Printing Medical Research Center, China Medical University Hospital , Taichung , Taiwan , ROC.

Abstract

Over the last decade, bioprinting has emerged as a promising technology in the fields of tissue engineering and regenerative medicine. With recent advances in additive manufacturing, bioprinting is poised to provide patient-specific therapies and new approaches for tissue and organ studies, drug discoveries and even food manufacturing. Manufacturing Readiness Level (MRL) is a method that has been applied to assess manufacturing maturity and to identify risks and gaps in technology-manufacturing transitions. Technology Readiness Level (TRL) is used to evaluate the maturity of a technology. This paper reviews recent advances in bioprinting following the MRL scheme and addresses corresponding MRL levels of engineering challenges and gaps associated with the translation of bioprinting from lab-bench experiments to ultimate full-scale manufacturing of tissues and organs. According to our step-by-step TRL and MRL assessment, after years of rigorous investigation by the biotechnology community, bioprinting is on the cusp of entering the translational phase where laboratory research practices can be scaled up into manufacturing products specifically designed for individual patients.

KEYWORDS:

Additive manufacturing; biofabrication; organ printing; regenerative medicine; scaffold; tissue engineering

PMID:
27023266
DOI:
10.3109/07388551.2016.1163321
[Indexed for MEDLINE]

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