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Arch Gynecol Obstet. 2016 Jun;293(6):1339-45. doi: 10.1007/s00404-016-4058-1. Epub 2016 Mar 29.

Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis.

Author information

1
Department of Endocrinology, The People's Hospital of Deyang City, Deyang, 618000, Sichuan, China.
2
Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, Sichuan, China.
3
Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, Sichuan, China. Lss219219@sina.cn.

Abstract

OBJECTIVE:

To assess the correlation between serum 25-hydroxy vitamin D [25(OH)D] status and outcomes of in vitro fertilization (IVF) in infertile women through review systematically.

METHODS:

We used Embase, Pubmed, and Cochrane database to identify all studies that assessed the correlation between serum vitamin D levels and IVF outcomes in infertile women up until 30 June 2015, with the restricted language of English. We included studies that compared IVF outcomes between infertile women vitamin D <20 ng/ml and vitamin D ≥20 ng/ml. The results were summarized using Stata 12.0 software. For studies reported dichotomous outcomes (clinical pregnancy rate and live birth rate), we pooled the relative risks ratios (RRs) and 95 % confidence intervals (CIs) in a random effects model.

RESULTS:

Our search resulted in the retrieval and screening of 134 studies. Of those, five studies were included in our meta-analysis. The risk for lower clinical pregnancy rate was not significantly increased in the deficient group (RR 0.88, 95 % CI 0.69-1.11). Lower vitamin D status was associated with lower live birth rate (RR 0.76, 95 % CI 0.61-0.93).

CONCLUSION:

There is no significant correlation between deficient serum vitamin D level and lower clinical pregnancy rate in infertile woman undergoing in vitro fertilization. On the other hand, deficient vitamin D level was related to lower live birth rate.

KEYWORDS:

Meta; Vitamin D; Vitro fertilization outcomes

PMID:
27022933
DOI:
10.1007/s00404-016-4058-1
[Indexed for MEDLINE]

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