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Pediatr Hematol Oncol. 1989;6(2):173-9.

Effects of 3-deazaadenosine, an inducer of HL-60 cell differentiation, on human blood cells in vitro.

Author information

1
Department of Pharmacology, University of Tromsø, Norway.

Abstract

The adenosine analogue 3-deazaadenosine (c3 Ado) induces differentiation of human promyelocytic leukemia HL-60 cells in vitro. c3 Ado affects in vitro viability and growth of cells involved indirectly (cytokine-producing cells) and directly (transformed myeloid cells) in leukemic cell differentiation. Growth inhibition of proliferating cells is achieved at c3 Ado concentrations between 10-100 microM. Concentrations higher than 100 microM affect viability of proliferating and nonproliferating cells.

PMID:
2702071
DOI:
10.3109/08880018909034283
[Indexed for MEDLINE]

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