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Presse Med. 2016 Dec;45(12 Pt 1):1096-1101. doi: 10.1016/j.lpm.2016.02.021. Epub 2016 Mar 25.

[What brings neurobiology to addictions?]

[Article in French]

Author information

1
Université Paris Descartes, CNRS ERL 3649 « Neuroplasticité et thérapies des addictions », Inserm UMR-S 1124, 45, rue des Saints-Pères, 75006 Paris, France.
2
Université Paris Descartes, CNRS ERL 3649 « Neuroplasticité et thérapies des addictions », Inserm UMR-S 1124, 45, rue des Saints-Pères, 75006 Paris, France. Electronic address: florence.noble@parisdescartes.fr.

Abstract

Addictions are multifactorial, and there are no experimental models replicating all aspects of this pathology. The development of animal models reproducing the clinical symptoms of addictions allows significant advances in the knowledge of the neurobiological processes involved in addiction. Preclinical data highlight different neuroadaptations according to the routes of administration, speeds of injection and frequencies of exposure to drugs of abuse. The neuroadaptations induced by an exposure to drugs of abuse follow dynamic processes in time. Despite significant progresses in the knowledge of neurobiology of addictions allowing to propose new therapeutic targets, the passage of new drugs in clinical is often disappointing. The lack of treatment efficacy reported in clinical trials is probably due to a very important heterogeneity of patients with distinct biological and genetic factors, but also with different patterns of consumption that can lead to different neuroadaptations, as clearly observed in preclinical studies.

PMID:
27020520
DOI:
10.1016/j.lpm.2016.02.021
[Indexed for MEDLINE]

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