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World J Methodol. 2016 Mar 26;6(1):112-7. doi: 10.5662/wjm.v6.i1.112. eCollection 2016 Mar 26.

Potential effects of curcumin on peroxisome proliferator-activated receptor-γ in vitro and in vivo.

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Mohsen Mazidi, Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.


Natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists are found in food and may be important for health through their anti-inflammatory properties. Curcumin (Cur) is a bright yellow spice, derived from the rhizome of Curcuma longa Linn. It has been shown to have many biological properties that appear to operate through diverse mechanisms. Some of these potentially beneficial effects of Cur are due to activation of the nuclear transcription factor PPAR-γ. It is reported (using in vitro and in vivo models) that Cur plays a potential role against several diseases. In this review article, we present the current literature on the effects of Cur on the modulation of inflammatory processes that are mediated through PPAR-γ.


Anti-inflammatory; Curcumin; Peroxisome proliferator-activated receptor-γ

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