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Hum Gene Ther. 2016 Apr;27(4):287-94. doi: 10.1089/hum.2016.024.

Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis.

Author information

1
1 Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute , Boston, Massachusetts.
2
2 Howard Hughes Medical Institute, Harvard Stem Cell Institute , Harvard Medical School, Boston, Massachusetts.
3
3 Chemical Biology Program, Harvard University , Cambridge, Massachusetts.

Abstract

Since its introduction in early 1980s, the zebrafish (Danio rerio) has become an invaluable vertebrate animal model system to study many human disorders in almost all systems, from hepatic and brain pathology, to autoimmune and psychiatric disorders. Hematopoiesis between zebrafish and mammals is highly conserved, making the zebrafish an attractive model to study hematopoietic development and blood disorders. Unique attributes of the zebrafish include the ability to perform large-scale genetic and chemical screens in vivo, study development at the cellular level, and use transgenic fish to dissect mechanisms of disease or drug effects. This review summarizes major discoveries that helped define molecular control of hematopoiesis in vertebrates and specific contributions from studies in zebrafish.

PMID:
27018965
PMCID:
PMC4841069
DOI:
10.1089/hum.2016.024
[Indexed for MEDLINE]
Free PMC Article

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