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Plant Signal Behav. 2016;11(4):e1161876. doi: 10.1080/15592324.2016.1161876.

Interaction between vitamin B6 metabolism, nitrogen metabolism and autoimmunity.

Author information

1
a Department of Botany and Plant Biology , University of Geneva , Geneva , Switzerland.

Abstract

The essential micronutrient vitamin B6 is best known in its enzymatic cofactor form, pyridoxal 5'-phosphate (PLP). However, vitamin B6 comprises the amine pyridoxamine 5'-phosphate (PMP) and the alcohol pyridoxine 5'-phosphate (PNP) in addition to PLP, as well as their corresponding non-phosphorylated forms. The different B6 forms (called vitamers) are enzymatically interconverted in a ubiquitous salvage pathway. Recently, we have shown that balancing the ratio of the different B6 vitamers in particular PMP by the PMP/PNP oxidase PDX3 is essential for growth and development in Arabidopsis thaliana. Intriguingly, nitrate to ammonium conversion is impaired in pdx3 mutants, such that the mutants become ammonium-dependent, suggesting an interaction between vitamin B6 and nitrogen metabolism. In addition, we found a strong up-regulation of genes related to plant defense. Here, we further show that pdx3 mutants display a temperature-sensitive phenotype that is typical of autoimmune mutants and is possibly connected to the impaired nitrogen metabolism.

KEYWORDS:

Arabidopsis thaliana; PDX3; autoimmunity; nitrogen metabolism; plant defense; pyridoxamine/pyridoxine phosphate oxidase; vitamin B6; vitamin B6 salvage

PMID:
27018849
PMCID:
PMC4883958
DOI:
10.1080/15592324.2016.1161876
[Indexed for MEDLINE]
Free PMC Article

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