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Neuron. 1989 Nov;3(5):563-72.

A brain-specific transcription activator.

Author information

1
Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.

Abstract

We have identified a DNA binding protein, named BETA, that interacts with the same (B) transcriptional regulatory sequence as the known transcription factor NF-kappa B. BETA is found only in gray matter throughout the brain, and not in a variety of other rat tissues. Two binding sites for BETA are present adjacent to the promoter of the rat proenkephalin gene. Transfection of primary brain cultures that express BETA, with a reporter gene driven by the SV40 promoter linked to BETA DNA binding sites, results in transcriptional activation. We infer that BETA is a brain-specific transcription activator.

PMID:
2701844
DOI:
10.1016/0896-6273(89)90266-3
[Indexed for MEDLINE]

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