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Biochem Biophys Res Commun. 2016 Apr 29;473(2):530-6. doi: 10.1016/j.bbrc.2016.03.107. Epub 2016 Mar 23.

Protective effects of Lactobacillus rhamnosus GG against dyslipidemia in high-fat diet-induced obese mice.

Author information

1
School of Life Science, Handong Global University, Pohang, Gyungbuk 791-708, Republic of Korea.
2
School of Life Science, Handong Global University, Pohang, Gyungbuk 791-708, Republic of Korea. Electronic address: ckhyun@handong.edu.

Abstract

Recent reports suggest that gut microbiota can be a major determinant of dyslipidemia and non-alcoholic fatty liver disease (NAFLD) and its modulation by treating probiotics is a valid strategy to exert a protective effect. In this study, high-fat diet (HFD)-fed mice were orally administrated with Lactobacillus rhamnosus GG (LGG) for 13 weeks. Significant reductions in the weights of the liver, mesenteric and subcutaneous adipose tissues were observed in LGG-treated HFD-fed mice compared to LGG-non-treated controls. The serum levels of triglyceride and cholesterol were also significantly reduced in LGG-treated mice. Gut microbial composition analysis showed that shifts in the diversity of dominant gut bacteria were caused by HFD and restored by LGG treatment. A remarkable decrease of hepatic fat content was also observed in LGG-treated mice, accompanied by downregulated expressions of lipogenic and pro-inflammatory genes in the liver. LGG-treated mice had lower expression levels of genes involved in cholesterol synthesis, but conversely, higher expression levels of cholesterol efflux-related genes compared to LGG-non-treated controls. The cholesterol-lowering effect of LGG was also found to be mediated by suppression of FXR and FGF15 signaling, resulting in the upregulation of hepatic CYP7A1. Our findings confirm a therapeutic potential of probiotics for ameliorating dyslipidemia and NAFLD.

KEYWORDS:

Cholesterol; Dyslipidemia; Gut microbiota; Lactobacillus rhamnosus GG; Non-alcoholic fatty liver disease (NAFLD)

PMID:
27018382
DOI:
10.1016/j.bbrc.2016.03.107
[Indexed for MEDLINE]

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