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Ophthalmology. 2016 Jun;123(6):1237-44. doi: 10.1016/j.ophtha.2016.01.036. Epub 2016 Mar 23.

Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract.

Author information

1
Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom.
2
Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom; University of Warwick Medical School, Coventry, United Kingdom.
3
Department of Ophthalmology, Kings College London, London, United Kingdom.
4
London School of Hygiene and Tropical Medicine, London, United Kingdom.
5
Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom; Department of Ophthalmology, Kings College London, London, United Kingdom. Electronic address: chris.hammond@kcl.ac.uk.

Abstract

PURPOSE:

To determine the heritability of nuclear cataract progression and to explore prospectively the effect of dietary micronutrients on the progression of nuclear cataract.

DESIGN:

Prospective cohort study.

PARTICIPANTS:

Cross-sectional nuclear cataract and dietary measurements were available for 2054 white female twins from the TwinsUK cohort. Follow-up cataract measurements were available for 324 of the twins (151 monozygotic and 173 dizygotic twins).

METHODS:

Nuclear cataract was measured using a quantitative measure of nuclear density obtained from digital Scheimpflug images. Dietary data were available from EPIC food frequency questionnaires. Heritability was modeled using maximum likelihood structural equation twin modeling. Association between nuclear cataract change and micronutrients was investigated using linear and multinomial regression analysis. The mean interval between baseline and follow-up examination was 9.4 years.

MAIN OUTCOME MEASURES:

Nuclear cataract progression.

RESULTS:

The best-fitting model estimated that the heritability of nuclear cataract progression was 35% (95% confidence interval [CI], 13-54), and individual environmental factors explained the remaining 65% (95% CI, 46-87) of variance. Dietary vitamin C was protective against both nuclear cataract at baseline and nuclear cataract progression (β = -0.0002, P = 0.01 and β = -0.001, P = 0.03, respectively), whereas manganese and intake of micronutrient supplements were protective against nuclear cataract at baseline only (β = -0.009, P = 0.03 and β = -0.03, P = 0.01, respectively).

CONCLUSIONS:

Genetic factors explained 35% of the variation in progression of nuclear cataract over a 10-year period. Environmental factors accounted for the remaining variance, and in particular, dietary vitamin C protected against cataract progression assessed approximately 10 years after baseline.

PMID:
27016950
PMCID:
PMC4882156
DOI:
10.1016/j.ophtha.2016.01.036
[Indexed for MEDLINE]
Free PMC Article

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