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Exp Hematol. 2016 Jun;44(6):451-7. doi: 10.1016/j.exphem.2016.03.004. Epub 2016 Mar 23.

Caught in a Wnt storm: Complexities of Wnt signaling in hematopoiesis.

Author information

1
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: F.J.T.Staal@lumc.nl.
2
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

Abstract

The Wnt signaling pathway is an evolutionary conserved pathway that is involved in the development of almost every organ system in the body and provides self-renewal signals for most, if not all, adult stem cell systems. In recent years, this pathway has been studied by various research groups working on hematopoietic stem cells, resulting in contradicting conclusions. Here, we discuss and interpret the results of these studies and propose that Wnt dosage, the source of hematopoietic stem cells, and interactions with other pathways explain these disparate results.

PMID:
27016274
DOI:
10.1016/j.exphem.2016.03.004
[Indexed for MEDLINE]

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