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J Biol Phys. 2016 Jun;42(3):339-50. doi: 10.1007/s10867-016-9410-y. Epub 2016 Mar 24.

Thermodynamic measures of cancer: Gibbs free energy and entropy of protein-protein interactions.

Author information

1
Information and Computer Science Department, University of Massachusetts, Amherst, MA, 01003, USA.
2
Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA.
3
Department of Biostatistics, Harvard Chan School of Public Health, Boston, MA, 02115, USA.
4
Department of Oncology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada. jtus@phys.ualberta.ca.
5
Department of Physics, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada. jtus@phys.ualberta.ca.
6
Pediatric Hematology Oncology, Floating Hospital for Children at Tufts Medical Center, Boston, MA, USA.
7
Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA.
8
Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA, 02111, USA.

Abstract

Thermodynamics is an important driving factor for chemical processes and for life. Earlier work has shown that each cancer has its own molecular signaling network that supports its life cycle and that different cancers have different thermodynamic entropies characterizing their signaling networks. The respective thermodynamic entropies correlate with 5-year survival for each cancer. We now show that by overlaying mRNA transcription data from a specific tumor type onto a human protein-protein interaction network, we can derive the Gibbs free energy for the specific cancer. The Gibbs free energy correlates with 5-year survival (Pearson correlation of -0.7181, p value of 0.0294). Using an expression relating entropy and Gibbs free energy to enthalpy, we derive an empirical relation for cancer network enthalpy. Combining this with previously published results, we now show a complete set of extensive thermodynamic properties and cancer type with 5-year survival.

KEYWORDS:

5-year survival; Cancer; Entropy; Gibbs free energy; Protein-protein interactions; Signaling networks

PMID:
27012959
PMCID:
PMC4942417
DOI:
10.1007/s10867-016-9410-y
[Indexed for MEDLINE]
Free PMC Article

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