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Cell Res. 2016 Apr;26(4):457-83. doi: 10.1038/cr.2016.40. Epub 2016 Mar 25.

Ubiquitin signaling in immune responses.

Hu H1, Sun SC2,3.

Author information

1
Department of Rheumatology and Immunology, State Key Laboratory of Biotherapy & Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
2
Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Unit 902, Houston, TX 77030, USA.
3
The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.

Abstract

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in diverse biological processes, including different aspects of immune functions. Ubiquitination regulates pattern-recognition receptor signaling that mediates both innate immune responses and dendritic cell maturation required for initiation of adaptive immune responses. Ubiquitination also regulates the development, activation, and differentiation of T cells, thereby maintaining efficient adaptive immune responses to pathogens and immunological tolerance to self-tissues. Like phosphorylation, ubiquitination is a reversible reaction tightly controlled by the opposing actions of ubiquitin ligases and deubiquitinases. Deregulated ubiquitination events are associated with immunological disorders, including autoimmune and inflammatory diseases.

PMID:
27012466
PMCID:
PMC4822134
DOI:
10.1038/cr.2016.40
[Indexed for MEDLINE]
Free PMC Article

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