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J Pediatric Infect Dis Soc. 2016 Jun;5(2):e9-e12. doi: 10.1093/jpids/piw001. Epub 2016 Mar 24.

Vertical Transmission of Histoplasmosis Associated With Anti-Tumor Necrosis Factor Therapy.

Author information

1
Division of Pediatric Infectious Diseases, Department of Pediatrics.
2
Division of Infectious Diseases.
3
Department of Internal Medicine.
4
Tennessee Maternal Fetal Medicine, Nashville.
5
Division of Gastroenterology, Department of Medicine, UCSF Medical Center, San Francisco, California.
6
Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine.

Abstract

Therapeutics blocking the activity of tumor necrosis factor (anti-TNF) are a risk factor for invasive fungal infections; however, infectious risks to infants born to mothers receiving anti-TNF therapy are not well defined. We report a case of vertical transmission of disseminated histoplasmosis in a mother-infant pair exposed to anti-TNF therapy.

KEYWORDS:

histoplasmosis; immunocompromised host; infant; tumor necrosis factor; vertical transmission

PMID:
27012275
PMCID:
PMC6280983
DOI:
10.1093/jpids/piw001
[Indexed for MEDLINE]
Free PMC Article

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