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N Am J Med Sci. 2016 Jan;8(1):40-6. doi: 10.4103/1947-2714.175206.

The Pathogenesis of Rheumatoid Arthritis is Associated with Milk or Egg Allergy.

Author information

1
Institue of Allergy and Immunology, School of Medicine, Shen Zhen University, Shenzhen, China.
2
Department of Rheumatism, Traditional Chinese Medicine, The Sixth People's Hospital of Shenzhen City, Shenzhen, China.
3
Institue of Allergy and Immunology, School of Medicine, Shen Zhen University, Shenzhen, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China.

Abstract

BACKGROUND:

Rheumatoid arthritis (RA) is a very complicated autoimmune disease with apparent synovial hyperplasia and cartilage and bone destruction.

AIMS:

In the present study, we aimed to determine whether the pathogenesis of RA correlates with food allergy and which allergen(s) are relevant.

MATERIALS AND METHODS:

We used type-II collagen (CII) to induce arthritis (collagen-induced arthritis, CIA) model in Wistar rats, and the development of arthritis was evaluated accordingly by scoring system. Proinflammatory cytokine levels in plasma were measured by enzyme-linked immunosorbent assay (ELISA), and concentrations of circulating immune complexes (CICs) were analyzed by C1q solid phase method. Furthermore, food-specific immunoglobulin G (IgG) and immunoglobulin E (IgE) levels were determined in the CIA model.

RESULTS:

In the CIA model, we found that levels of tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1, IL-6, and IL-17, as well as CICs, were elevated significantly. Moreover, concentrations of milk- or egg-specific IgG and IgE were enhanced strikingly in CIA rats.

CONCLUSION:

The results suggest that pathogenesis of RA correlates closely to increased egg- or milk-specific antibodies.

KEYWORDS:

Egg allergen; food allergy; milk allergen; proinflammatory cytokines; rheumatoid arthritis (RA)

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