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Med Sci (Paris). 2016 Mar;32(3):253-9. doi: 10.1051/medsci/20163203009. Epub 2016 Mar 23.

[Immunopathology of psoriasis: from bench to bedside].

[Article in French]

Author information

1
Inserm U976, laboratoire oncodermatologie, immunologie et cellules souches cutanées, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France - Université Paris VII Paris Diderot, Sorbonne Paris Cité, Paris, France - Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France.
2
Université Paris VII Paris Diderot, Sorbonne Paris Cité, Paris, France - Laboratoire de pathologie, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France - Inserm U1165, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France.
3
Inserm U976, laboratoire oncodermatologie, immunologie et cellules souches cutanées, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France - Université Paris VII Paris Diderot, Sorbonne Paris Cité, Paris, France - OREGA Biotech, 15, chemin du Saquin, 69130 Écully, France.

Abstract

Psoriasis is a frequent inflammatory disease that involves mostly the skin and sometimes the joints. This chronic disease is rarely life-threatening but impairs significantly the patient's quality of life. It is characterized, in its typical form, by erythematous and squamous plaques with well-defined borders, associated with increased proliferation of the keratinocytes, inflammation and greater number of dilated blood vessels in the upper dermis. A role of Th1 CD4 T cells was initially suspected. More recently, Th17 CD4 T cells have been shown to play a major role in the disease. It has led to the development of Th17 inhibitors, such as anti-IL-23 (cytokine that induces Th17 CD4 T cell differentiation), anti-IL-17, anti-IL-17RA (IL-17 receptor) and anti-IL-22 (cytokines that are notably produced by Th17 CD4 T cells).

PMID:
27011243
DOI:
10.1051/medsci/20163203009
[Indexed for MEDLINE]
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