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Int J Mol Sci. 2016 Mar 22;17(3):431. doi: 10.3390/ijms17030431.

Molecular Insight into Gut Microbiota and Rheumatoid Arthritis.

Wu X1,2, He B3,4, Liu J5,6, Feng H7,8, Ma Y9,10, Li D11,12,13, Guo B14,15,16, Liang C17,18,19, Dang L20,21, Wang L22,23, Tian J24, Zhu H25,26, Xiao L27,28, Lu C29,30,31, Lu A32,33,34,35,36,37, Zhang G38,39,40,41.

Author information

1
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. wxho0606@163.com.
2
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. wxho0606@163.com.
3
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. hebinghb@gmail.com.
4
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. hebinghb@gmail.com.
5
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. liujin_hkbu@163.com.
6
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. liujin_hkbu@163.com.
7
Guanghua Integrative Hospital, Shanghai 200000, China. 13816671472@163.com.
8
Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. 13816671472@163.com.
9
Guanghua Integrative Hospital, Shanghai 200000, China. mayinghui021@126.com.
10
Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. mayinghui021@126.com.
11
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. lidefang@163.com.
12
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. lidefang@163.com.
13
Research Group of Bone and Joint Diseases, HKBU Institute of Science & Technology, Haimen 226100, China. lidefang@163.com.
14
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. borisguo@hkbu.edu.hk.
15
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. borisguo@hkbu.edu.hk.
16
Research Group of Bone and Joint Diseases, HKBU Institute of Science & Technology, Haimen 226100, China. borisguo@hkbu.edu.hk.
17
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. liangchao512@163.com.
18
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. liangchao512@163.com.
19
Research Group of Bone and Joint Diseases, HKBU Institute of Science & Technology, Haimen 226100, China. liangchao512@163.com.
20
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. danglei_hkbu@163.com.
21
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. danglei_hkbu@163.com.
22
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. luyaoben@126.com.
23
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. luyaoben@126.com.
24
Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. 14441098@life.hkbu.edu.hk.
25
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. hlzhu@hkbu.edu.hk.
26
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. hlzhu@hkbu.edu.hk.
27
Guanghua Integrative Hospital, Shanghai 200000, China. 13701888178@163.com.
28
Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. 13701888178@163.com.
29
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. lv_cheng0816@163.com.
30
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. lv_cheng0816@163.com.
31
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100000, China. lv_cheng0816@163.com.
32
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. aipinglu@hkbu.edu.hk.
33
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. aipinglu@hkbu.edu.hk.
34
Guanghua Integrative Hospital, Shanghai 200000, China. aipinglu@hkbu.edu.hk.
35
Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. aipinglu@hkbu.edu.hk.
36
Research Group of Bone and Joint Diseases, HKBU Institute of Science & Technology, Haimen 226100, China. aipinglu@hkbu.edu.hk.
37
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100000, China. aipinglu@hkbu.edu.hk.
38
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. zhangge@hkbu.edu.hk.
39
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong SAR, China. zhangge@hkbu.edu.hk.
40
Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai 200000, China. zhangge@hkbu.edu.hk.
41
Research Group of Bone and Joint Diseases, HKBU Institute of Science & Technology, Haimen 226100, China. zhangge@hkbu.edu.hk.

Abstract

Rheumatoid arthritis (RA) is a systemic, inflammatory, and autoimmune disorder. Gut microbiota play an important role in the etiology of RA. With the considerable progress made in next-generation sequencing techniques, the identified gut microbiota difference between RA patients and healthy individuals provides an updated overview of the association between gut microbiota and RA. We reviewed the reported correlation and underlying molecular mechanisms among gut microbiota, the immune system, and RA. It has become known that gut microbiota contribute to the pathogenesis of RA via multiple molecular mechanisms. The progressive understanding of the dynamic interaction between gut microbiota and their host will help in establishing a highly individualized management for each RA patient, and achieve a better efficacy in clinical practice, or even discovering new drugs for RA.

KEYWORDS:

gut microbiota; molecular mechanism; rheumatoid arthritis

PMID:
27011180
PMCID:
PMC4813281
DOI:
10.3390/ijms17030431
[Indexed for MEDLINE]
Free PMC Article

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